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FLASH GENE
Symbol RFC4 contributors: mlc/npt - updated : 12-01-2008
HGNC name replication factor C (activator 1) 4, 37kDa
HGNC id 9972
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestivesalivary gland   highly
Endocrineneuroendocrinepituitary  highly
Reproductivemale systemprostate   
Respiratoryrespiratory tractlarynx  highly
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a PCNA binding region
  • an ATP binding domain
  • a DEAD/H box (Asp-Glu-Ala-Asp/His)
  • mono polymer heteromer , pentamer
    HOMOLOGY
    interspecies homolog to Drosophila CG8142
    homolog to C.elegans rfc-4
    Homologene
    FAMILY
  • activator 1,36 to 40 kDa subunits family
  • CATEGORY regulatory , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • activator of DNA polymerases
  • maybe involved in the elongation of multiprimed DNA template
  • CELLULAR PROCESS nucleotide, replication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of complex A-1, DNA polymerase accessory protein "clamp loader", ATP dependent, required to assemble PCNA and polymerase delta on the DNA template
  • heteropentamer of subunits of 140/145, 40, 38, 37 and 36.5 kDa
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • binding to PCNA
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS