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FLASH GENE
Symbol CRELD2 contributors: mct/pgu - updated : 16-10-2013
HGNC name cysteine-rich with EGF-like domains 2
HGNC id 28150
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestineduodenum moderately
 intestinelarge intestinecaecumappendix vermicularmoderately
 salivary gland   moderately
 stomach   predominantly
Endocrinepancreas   predominantly
 thyroid   moderately
Respiratoryrespiratory tracttrachea  moderately
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text lung, liver, thymus, spleen and heart
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • tryptophan-glutamic acid rich domain (WE)
  • EGF binding domain
  • Ca binding domain
  • EGF/Ca binding domain
  • furin cysteine-rich domain
  • HOMOLOGY
    interspecies homolog to rattus Creld2 (77,08 pc)
    homolog to murine Creld2 (75,71 pc)
    Homologene
    FAMILY
  • CRELD family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    text localized in ER
    basic FUNCTION
  • secreted CRELD2 isoforms may modulate CRELD1 function by competitive binding
  • may acts as an extracellular competitor of CRELD1
  • CRELD2 may regulates CRELD1 function
  • may play a role in AVSD
  • could be a novel mediator in regulating the onset and progression of various ER stress-associated diseases
  • MANF and CRELD2 are genotype-specific ER stress response proteins with substrate specificities
  • exogenous CRELD2 promotes GDF2-induced ectopic bone formation and matrix mineralization, whereas silencing CRELD2 expression diminishes GDF2-induced bone formation and matrix mineralization
  • CELLULAR PROCESS cell life
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CRELD2 may be directly regulated by GDF2
  • CRELD2 and MANF, are oppositely regulated by the overexpression of 78&
  • 8201;kDa glucose-regulated protein (HSPA5)
    cell & other
    REGULATION
    induced by ER stress
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS