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FLASH GENE
Symbol FBXL20 contributors: mlc - updated : 17-11-2007
HGNC name F-box and leucine-rich repeat protein 20
HGNC id 24679
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
 mouthtongue  predominantly
Lymphoid/Immunespleen    
Reproductivefemale systembreastmammary gland predominantly
 female systemovary   
Respiratoryrespiratory tractlarynx   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose   
cell lineage
cell lines
fluid/secretion blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one N-terminal F box
  • 12 tandem leucine-rich repeats
  • a CAAX domain, a carboxyl-terminal membrane-sorting signal induced by prenylation
  • HOMOLOGY
    interspecies homolog to murine Fbxl20 (99.8pc)
    intraspecies homolog to 76.8 p 100 similar throughout to FBXL2
    Homologene
    FAMILY
    CATEGORY unknown/unspecified , antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text localized on presynaptic membrane
    basic FUNCTION
  • may be involved in ubiquitination
  • synapse-localized E3 ubiquitin ligase, which regulates neural transmission
  • having an essential function in regulating proteasome-mediated degradation of RIM1 required for synaptic tuning
  • plays a significant role in regulation of neurotransmitter release
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of SCF complex, formed by SKP1, cullin and F-box proteins
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SKP1A and CUL1
  • directly binds and ubiquitinates RIMS1, a modulator of presynaptic plasticity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS