basic FUNCTION
| anti-apoptotic molecule that may undergo a cytoplasm-nucleus-nucleolus translocation (Hao 2006) |
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may be involved in cell differentiation, and it might exert universal and possibly important physiological functions under the regulation of Ras (Hao 2006) |
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essential conserved Fe/S cluster protein implicated in extramitochondrial Fe/S cluster assembly, similar to other components of the so-called CIA (cytoplasmic Fe/S cluster assembly) pathway although partially localized to the mitochondrial intermembrane space (Zhang 2008) |
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suppressor of gastric cancer cell proliferation and might play an important role in the development of gastric cancer (Zhang 2008) |
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played an important role in the differentiation of Colorectal cancer (CRC) cells, and the differential expression of CIAPIN1 in CRC was closely related to prognosis |
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CIAPIN1 and GLRX3 might play cooperatively essential roles in embryogenesis as iron-sulfur cluster proteins |
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implicated in cytosolic iron-sulfur (Fe/S) protein biogenesis |
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is the first identified Fe/S protein imported into the mitochondrial intermembrane space (IMS), raising the possibility that it plays a role in cytosolic Fe/S cluster biogenesis also once trapped in the IMS |
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participate in the process of proliferation and tumorigenicity for several cancers |
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implicated in several processes, such as apoptosis, cell division, angiogenesis and Fe/S protein biogenesis |
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is an antiapoptotic molecule that confers factor-independent survival on hematopoietic cells |
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essential for both autonomous and extrinsic regulation of fetal liver hematopoiesis |
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is a potential tumor suppressor |
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involved in cell survival including dopaminergic neuronal cells |