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FLASH GENE
Symbol CLTB contributors: - updated : 07-01-2006
HGNC name clathrin, light polypeptide (Lcb)
HGNC id 2091
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach   highly
Lymphoid/Immunethymus   highly
Reproductivefemale systembreastmammary gland highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , dimer
HOMOLOGY
interspecies ortholog to murine Cltb
homolog to C.elegans T05B11.3
Homologene
FAMILY
CATEGORY regulatory , structural protein
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,cytosolic,vesicle
text
  • translocated to plasma membrane through AP2 binding
  • synaptic vesicles
  • cytoplasmic face of coated pits and vesicles
  • basic FUNCTION
  • acting as the main structural component of the lattice covering the cytoplasmic face of the coated pits and coated vesicles in which specific macromolecules are entrapped in the process of receptor-mediated endocytosis
  • involved in vesicle budding
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS endocytosis transport
    PATHWAY
    metabolism
    signaling
    a component
  • a large and soluble protein composed of heavy chains and light chains
  • clathrin coats are formed from molecules containing 3 heavy chains and 3 light chains
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
    calcium Ca2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS