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FLASH GENE
Symbol CHMP2A contributors: mct - updated : 05-11-2010
HGNC name chromatin modifying protein 2A
HGNC id 30216
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary  highly
Hearing/Equilibriumearinnercochlea highly
Skin/Tegumentskin   highly
Urinarykidney   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C-terminal fragments of all ESCRT-III proteins, including CHMP2A, CHMP1B, VPS24, CHMP4A, CHMP6, and CHMP5, activated VPS4A suggesting that it disassembles ESCRT-III heteropolymers by affecting each component protein
  • HOMOLOGY
    Homologene
    FAMILY
  • SNF7 family
  • chromatin-modifying protein/charged multivesicular body protein (CHMP) family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • required for multivesicular bodies (mvbs) formation and sorting of endosomal cargo proteins into mvbs
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    ESCRT-III (CHMP) proteins pathhway
    a component
  • component of the endosomal sorting required for transport complex III (ESCRT-III), at least composed of CHMP1A, CHMP1B, CHMP2A, CHMP2B, CHMP3/VPS24, CHMP4A/SHAX2, CHMP4B/SHAX1, CHMP4C/SHAX3, CHMP5/SNF7DC2 and CHMP6
  • with VPS24, copolymerized in solution, and their membrane targeting was cooperatively enhanced on planar lipid bilayers
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with EIF2B5, NOL4, TTC19
  • binding between VTA1 and ESCRT-III proteins (CHMP1B, CHMP2A, VPS24) that is likely to complement VTA1 previously described ability to regulate VPS4 activity
  • AP1G2 specifically interacts with the ESCRT subunits VPS28 and CHMP2A
  • interactions between CDCA8 and CHMP2A, CHMP4B, CHMP4C, and CHMP6
  • strong interactions of MITD1 with CHMP1B, CHMP2A, and IST1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS