Selected-GenAtlas references SOURCE GeneCards NCBI Gene Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol OTULINL contributors: mct - updated : 08-12-2021
HGNC name OTU deubiquitinase with linear linkage specificity like
HGNC id 25629
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
HOMOLOGY
Homologene
FAMILY
  • FAM105 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nuclear envelope
    text
  • localizes to the ER membrane
  • basic FUNCTION
  • PPP1R1A, OTULINL, ENO2, and GNG5 are potential regulators of islet function
  • only putative pseudodeubiquitinase of the ovarian tumor protease (OTU domain) family
  • OTULINL functions through its ability to mediate protein-protein interactions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • OTULIN interferes with endosome-to-plasma membrane trafficking and the OTULIN-related OTULINL (FAM105A) resides at the endoplasmic reticulum (ER)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS