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FLASH GENE
Symbol DTX3 contributors: mct/npt - updated : 06-02-2010
HGNC name deltex 3 homolog (Drosophila)
HGNC id 24457
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a basic N terminus
  • a central proline-rich region
  • and a C-terminal RING finger domain, a motif often found in ubiquitin-protein isopeptide ligases (E3) (Takeyama 2003)
  • HOMOLOGY
    Homologene
    FAMILY
  • Deltex family, E3 ubiquitin ligases of the RING (Really interesting new gene)-H2 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • act as Notch signaling modifiers and may also regulate transcription through interactions with specific transcription factors (Takeyama 2003)
  • function as E3 ligases based on its capacity for self-ubiquitination (Takeyama 2003)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interact with ITCH and partially colocalize to endocytic vesicles, and ITCH targets DTX for lysosomal degradation (Chastagner 2006)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS