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FLASH GENE
Symbol PREX2 contributors: mct/npt - updated : 24-05-2016
HGNC name phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2
HGNC id 22950
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinethyroid    
Nervousbrainhindbraincerebellum  
Reproductivefemale systembreastmammary gland  
Respiratorylung    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a catalytic Dbl homology domain followed invariably by a lipid-binding pleckstrin homology (PH) domain
  • HOMOLOGY
    Homologene
    FAMILY
  • P-Rex family of Rac-GEFs proteins
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • guanine-nucleotide exchange factor, activating the small GTPase Rac
  • may serving as a novel link between Rac activation and the PI-3 kinase pathway
  • important regulator of Purkinje cell morphology and cerebellar function
  • functional role for PREX2 PH-domain-mediated inhibition of PTEN in regulating insulin sensitivity and glucose homeostasis, suggesting that loss of PREX2 expression may cause insulin resistance
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PTEN-interacting protein and negative regulator of PTEN in breast cancer
  • CXCL9 was involved in the invasion ability of hepatocellular carcinoma possibly through up-regulation of its potential effector PREX2
  • guanine nucleotide exchange factor (GEF) for RAC1 GTPase, facilitating the exchange of GDP for GTP on RAC1
  • RAC1 initiates its own inactivation by decreasing PREX2 GEF activity
  • reciprocal regulation of PREX2 by PTEN whereby loss of PTEN results in a dramatic increase in expression of PREX2 at the protein level
  • cell & other
    REGULATION
    Other regulated by phosphatidylinositol (3,4,5)-trisphosphate and the beta gamma subunits of heterotrimeric G proteins
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation      
    somatic mutations generate truncated or variant proteins that gain oncogenic activity in melanoma cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • is a candidate melanoma gene whose amplifications, rearrangements or mutations appeared to undergo positive selection in human melanoma genesis
  • Marker
    Therapy target
    ANIMAL & CELL MODELS