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FLASH GENE
Symbol THPO contributors: mct/npt/pgu - updated : 28-03-2012
HGNC name thrombopoietin
HGNC id 11795
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemuterus   
Respiratoryrespiratory tractlarynx   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text liver, spleen
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • EPO/TPO family
  • CATEGORY signaling growth factor
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • stimulator of platelet formation and involved in megakaryocyte growth
  • important growth factor for the megakaryocyte lineage, controlling its proliferation and differentiation
  • playing a proapoptotic role in the brain and contributing to the timing of neuronal selection by the neurotrophins
  • hematopoietic growth factor regulating platelet production
  • via activation of its receptor-bound JAK2 delays the NGF-dependent acquisition of neuronal phenotype and decreases neuronal survival by suppressing NGF-induced ERK activity
  • activates a number of secondary messengers that promote cell survival, proliferation and differentiation
  • negatively modulates cardiac inotropy and contributes to the myocardial depressing activity of septic shock serum
  • having ability to stimulate platelet production
  • potential role as a physiological regulator of coronary flow
  • with its receptor MPL are essential in the regulation of the hematopoietic stem and progenitors cells as well as for the differentiation of megakaryocytes into mature platelets
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • hematopoietic growth factor (MPL ligand)
  • TENC1 is an important new mediator in THPO/MPL pathway and has a positive affect on cellular growth, at least in part through its effect on the PI3K/Akt signaling
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) THPO
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS