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FLASH GENE
Symbol CTRB2 contributors: mct - updated : 09-11-2021
HGNC name chymotrypsinogen B2
HGNC id 2522
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepancreas exocrine     Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • first 18AA comprise a signal peptide that is cleaved off the zymogen upon entry into the ER
  • isoforms Precursor of pancreatic proteolytic enzymes
    HOMOLOGY
    interspecies homolog to murine Ctrb1
    intraspecies paralog to CTRB1
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • peptidase activity
  • playing a key role in the enteroendocrine system (
  • involved in the regulation of the incretin pathway, development of diabetes, and response to DPP-4 inhibitor treatment (
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP/GTP binding
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to pancreatic cancer
  • to diabetes mellitus
  • Variant & Polymorphism other
  • increased pancreatic cancer risk in carriers of CTRB2 exon 6 deletion alleles, impairing chymotrypsin B2 function and localization
  • CTRB2 deletion variant associated with risk of diabetes mellitus
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS