SUBCELLULAR LOCALIZATION
| extracellular
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| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,cytosolic,vesicle
|
| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
|
text
| localized both to the primary cilium and to the plasma membrane in ciliated cell-lines and primary cells |
basic FUNCTION
| mediating a fundamental developmental stage of ciliary formation and epithelial morphogenesis |
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implicated in mediating primary ciliary function |
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possible role for the extracellular domain of meckelin in mediating intracellular transport from the ER |
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required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication |
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is required for endoplasmic reticulum-associated degradation of surfactant protein C |
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having a role in basal body anchoring and establishing a ciliary gate during ciliogenesis |
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important role for meckelin in intraciliary transport of phototransduction molecules and their effects on subsequent outer segment morphogenesis and maintenance |