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FLASH GENE
Symbol SGSM1 contributors: mct - updated : 29-09-2017
HGNC name small G protein signaling modulator 1
HGNC id 29410
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Endocrineparathyroid    
 thyroid    
Nervousbrainforebraincerebral cortex   Mus musculus
 brainlimbic systemhippocampus   Mus musculus
 brainhindbraincerebellum   Mus musculus
 brainmidbrainsubstantia nigra   Mus musculus
Reproductivemale systemtestis   
Visualeye    
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousdopaminergic neuron Mus musculus
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text in later stages of development
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal RUN domain (RPIP8, UNC-14, and NESCA)
  • RAPID motifs
  • a C-terminal TBC domain (Tre-2, Bub2, and Cdc16) both of which are found in proteins of the GTPase activating protein (GAP) family, involved in the GTPase signaling pathway
  • HOMOLOGY
    Homologene
    FAMILY SGSM family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • modulator of RAP and RAB-mediated cellular signaling
  • modulator of the small G protein RAP and RAB-mediated neuronal signal transduction and vesicular transportation pathways
  • may be involved in motor activity control in basal ganglia as well as higher central nervous system (CNS) functions such as cognition and memory in cortex and hippocampus
  • can act as a RAB36 GAP in cells, suggesting that it links RAB9A function to RAB36 function in the endosomal system
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interact with RAP family proteins via novel RAP interacting domain (RAPID) motif
  • modulate the transcriptional activity of NURR1, the orphan nuclear receptor required for midbrain dopaminergic neuron differentiation
  • interact with several members of RAB family
  • TBC domain-containing protein that binds to RAB9A specifically
  • membrane-associated SGSM1 co-localizes with RAB36, and expression of SGSM1, decreases the amount of membrane-associated RAB36 protein
  • RAB9B can bind to SGSM1 probably in a similar manner as RAB9A
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS