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FLASH GENE
Symbol ENDOU contributors: mct/ - updated : 18/09/2008
HGNC name endonuclease, polyU-specific
HGNC id 14369
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
 mouthtongue  moderately
Reproductivefemale systemplacenta  highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • an N-terminal hydrophobic region of 18 amino acids typical of secretory proteins (signal peptide of 1.9 kda)
  • a SMB domain
  • isoforms Precursor a 350 aa mature peptide of 40.2 kda
    HOMOLOGY
    interspecies ortholog to murine Pp11r (84.8pc)
    Homologene
    FAMILY
  • ENDOU family
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • acting as a putative serine protease
  • can act as a tumor marker because of its specific association with various forms of cancer
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • HTR1B (its overexpression increasing HTR1B function)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS