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FLASH GENE
Symbol DUSP2 contributors: mct - updated : 06-01-2010
HGNC name dual specificity phosphatase 2
HGNC id 3068
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
cell lineage hematopoietic cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two N terminal CH2 domains
  • an extended active site sequence motif conserved in dual specificity phosphatases
  • HOMOLOGY
    Homologene
    FAMILY
  • protein-tyrosine phosphatase family
  • non-receptor class dual specificity subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • negative regulator of mitogen activated protein (MAP) kinase family
  • playing a role necessary and sufficient for TP53 -induced apoptosis and growth suppression
  • inducible, nuclear-specific, dual-specificity mitogen-activated protein (MAP) kinase phosphatase that is a transcription target of TP53 in signaling apoptosis and growth suppression
  • involved in ERK2 dephosphorylation, requiring association of its N-terminal domain with ERK2 that results in catalytic activation of the phosphatase
  • having a crucial role in E2F1-directed apoptosis
  • involved in stimulus-specific, and phosphatase-specific mechanism of MAPK1 regulation in the nucleus
  • with DUSP1, and DUSP10 are crucial players in the regulation of immune responses, but other members of the family, like the ERK-specific DUSP6, play a major role in development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • inactivating ERK1, ERK2
  • direct transcription target of E2F1 in signaling apoptosis
  • cell & other
    REGULATION
    activated by TP53 during apoptosis
    induced by in response to serum deprivation and oxidative stress
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS