basic FUNCTION
| zinc-finger transcription factor expressed in early development |
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may be having a role in maintenance of imprinted DNA methylation during the earliest multicellular stages of development |
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methylated TGCCGC hexanucleotide is the motif that is recognized by ZFP57 in all imprinting control regions (ICRs) and in several tens of additional loci, several of which are at least ZFP57-dependently methylated in ES cells |
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may recruit DNA methyltransferases to its target regions to maintain DNA methylation imprint, and this interaction is likely facilitated by TRIM28 |
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recognizes the methylated CpG within the TGCCGC element |