SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,mitochondria
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,Golgi
|
| intracellular,cytoplasm,organelle,endosome
|
text
| integral to membrane |
basic FUNCTION
| playing a role in autophagy |
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is essential for starvation-induced autophagosome formation |
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trafficking of ATG9A through the recycling endosomes is an essential step for autophagosome formation |
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ATG9A self-interacts as well, and this process promotes transport of ATG9A molecules through the Golgi apparatus, but the transport of ATG9A out of the ER is severely impacted after mutation of the conserved V515-C519 motif |
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RAB1B is associated with ATG9A vesicles and regulates autophagosome formation |
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ATG9A acts as a membrane-embedded funnel to facilitate lipid flipping and to redistribute lipids added to the outer leaflet of ATG9 vesicles, thereby enabling growth into autophagosomes |
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plays a key role in autophagy |
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is a scramblase that flips phospholipids between the two membrane leaflets, thus contributing to the expansion of the phagophore membrane in the early stages of autophagy |
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ATG9A plays a critical role in lipid mobilization from lipid droplets to autophagosomes and mitochondria, highlighting the importance of ATG9A in both autophagic and non-autophagic processes |
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critical role of ATG9A ubiquitination in oxidative stress-induced autophagy, endocytic trafficking and innate immunity |