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FLASH GENE
Symbol ATG9A contributors: mct - updated : 13-04-2022
HGNC name ATG9 autophagy related 9 homolog A (S. cerevisiae)
HGNC id 22408
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY APG9 family
CATEGORY transport
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,mitochondria
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,Golgi
intracellular,cytoplasm,organelle,endosome
text integral to membrane
basic FUNCTION
  • playing a role in autophagy
  • is essential for starvation-induced autophagosome formation
  • trafficking of ATG9A through the recycling endosomes is an essential step for autophagosome formation
  • ATG9A self-interacts as well, and this process promotes transport of ATG9A molecules through the Golgi apparatus, but the transport of ATG9A out of the ER is severely impacted after mutation of the conserved V515-C519 motif
  • RAB1B is associated with ATG9A vesicles and regulates autophagosome formation
  • ATG9A acts as a membrane-embedded funnel to facilitate lipid flipping and to redistribute lipids added to the outer leaflet of ATG9 vesicles, thereby enabling growth into autophagosomes
  • plays a key role in autophagy
  • is a scramblase that flips phospholipids between the two membrane leaflets, thus contributing to the expansion of the phagophore membrane in the early stages of autophagy
  • ATG9A plays a critical role in lipid mobilization from lipid droplets to autophagosomes and mitochondria, highlighting the importance of ATG9A in both autophagic and non-autophagic processes
  • critical role of ATG9A ubiquitination in oxidative stress-induced autophagy, endocytic trafficking and innate immunity
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ANXA2 is an autophagy modulator that regulates autophagosome formation by enabling appropriate ATG9A trafficking from endosomes to autophagosomes via actin
  • SNX18 regulates ATG9A trafficking from recycling endosomes
  • ATG9A is recruited to SNX18-induced tubules generated from recycling endosomes and accumulates in juxtanuclear recycling endosomes in cells lacking SNX18
  • SNX18 regulates ATG9A trafficking from recycling endosomes by recruiting DNM2
  • SNX4 mediates recycling of the lipid scramblase ATG9A, which drives expansion of nascent autophagosome membranes, from endolysosomes to early endosomes
  • ATG9A engages IQGAP1 and the ESCRT system to maintain Plasma membrane integrity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    causes axon-specific lesions including neuronal circuit dysgenesis
    tumoral     --over  
    associated with disease recurrence and overall survival in oral squamous cell carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • presence of ATG9A in the cytoplasm of tumor cells may be an independent biomarker for disease recurrence and survival in patients with oral squamous cell carcinoma
  • Therapy target
    ANIMAL & CELL MODELS