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FLASH GENE
Symbol ANAPC13 contributors: mct - updated : 03-09-2010
HGNC name anaphase promoting complex subunit 13
HGNC id 24540
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivegallbladder    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer complex
HOMOLOGY
interspecies ortholog to murine Anapc13
Homologene
FAMILY
  • APC (anaphase promoting complex) family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • promotes the stable association with the APC/C of the essential subunits CDC16 and CDC27
  • is required for the timely execution of APC/C-dependent cell cycle events
  • orchestrates progression through mitosis by decorating cell-cycle regulators with ubiquitin chains (Jin 2008)
  • CELLULAR PROCESS cell cycle, progression
    PHYSIOLOGICAL PROCESS
    text mitotic checkpoint regulator
    PATHWAY
    metabolism
    signaling
    a component
  • component of the anaphase promoting/cyclosome complex (APC/C) is a large E3 ubiquitin ligase containing at least ten different, evolutionarily conserved components
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS