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FLASH GENE
Symbol TRIM55 contributors: KTN/npt - updated : 03-02-2009
HGNC name tripartite motif-containing 55
HGNC id 14215
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   predominantly
Digestiveliver   moderately
Respiratoryrespiratory tractlarynx  moderately
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatum  highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text abundant in the fetal heart
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a RING-type zinc finger
  • a B-box type-2 zinc finger
  • a coiled-coil domain
  • a COS (C-terminal subgroup one signature) domain
  • mono polymer homomer , heteromer , oligo
    HOMOLOGY
    interspecies ortholog to murine Trim55 (85.8 pc)
    ortholog to rattus Trim55 (85.3 pc)
    Homologene
    FAMILY
  • C-II TRIM family
  • MURF subfamily
  • RBCC family
  • CATEGORY adaptor , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • may regulate gene expression and protein turnover in muscle cells
  • acting as a transient adaptor
  • playing a regulatory role in the assembly of sarcomeres
  • acting as an ubiquitin-protein ligase
  • CELLULAR PROCESS protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS development
    text
  • muscle development
  • PATHWAY
    metabolism
    signaling signal transduction
    a component
  • homooligomer
  • heterooligomer (probable)
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • interacting with titin/TTN
  • myosins
  • SQSTM1
  • NBR1
  • TRIM63
  • TRIM54
  • cell & other
    REGULATION
    Other downregulated during cardiac development
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS