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FLASH GENE
Symbol INTS7 contributors: mct - updated : 14-06-2023
HGNC name integrator complex subunit 7
HGNC id 24484
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly Homo sapiens
Endocrinepancreas   highly Homo sapiens
Lymphoid/Immunespleen   highly Homo sapiens
Reproductivemale systemtestis  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer complex
HOMOLOGY
interspecies ortholog to murine Ints7
Homologene
FAMILY multiprotein complex integrator family
CATEGORY RNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nucleus,nucleoplasm
intracellular,nucleus,chromatin/chromosome
text
  • INTS4, INTS7, INTS9 and INTS11 are both nuclear and cytoplasmic
  • basic FUNCTION
  • is recruited to the U1 and U2 snRNA genes and mediates the snRNA's 3' end processing
  • the integrator complex mediates RNA polymerase-II-dependent transcription
  • DTL-INTS7 intergenic region acts as a bidirectional promoter regardless of its orientation, and the functional minimal region was seen to be most probably inseparable within the intergenic region
  • DTL and INTS7 involved in DNA replication and transcription, respectively, could share a bidirectional promoter but have different regulatory mechanism
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the RNA polymerase II complex
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • stably associated with RNAPII
  • suppression of oxidative stress could be involved in the INTS7/ABCD3 co-regulatory mechanisms for bone marrow mesenchymal stem cells (BM-MSCs) proliferation and differentiation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    more upregulated in the Lung adenocarcinoma (LUAD) tissues than the adjacent normal tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • can be used as a potential prognostic marker for LUAD
  • Therapy target
    SystemTypeDisorderPubmed
    osteoarticularboneostéoporosis
    new potential candidates for osteoporosis therapy
    cancerlung 
    can be used as a potential therapy target for LUAD
    ANIMAL & CELL MODELS