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FLASH GENE
Symbol INTS9 contributors: mct - updated : 13-06-2023
HGNC name integrator complex subunit 9
HGNC id 25592
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer complex
HOMOLOGY
Homologene
FAMILY
  • RNA-metabolizing metallo-beta- lactamase-like family
  • INTS9 subfamily
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    text
  • INTS4, INTS7, INTS9 and INTS11 are both nuclear and cytoplasmic
  • basic FUNCTION
  • is recruited to the U1 and U2 snRNA genes and mediates the snRNA's 3' end processing
  • the integrator complex mediates RNA polymerase-II-dependent transcription
  • INTS4/9/11 are required for Cajal Body integrity
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the RNA polymerase II complex
  • INTS11 forms a stable complex with Integrator complex subunit 9 (INTS9) through their C-terminal domains (CTDs)
  • INTS4/9/11 ternary complex, constitutes Integrator's catalytic core
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • stably associated with RNAPII
  • INTS9-INTS11 interaction is crucial for the role of INT in snRNA 3prime-end processing
  • INTS4 binds to INTS9 and INTS11 only when they are associated with each other through heterodimerization of their C-terminal domains
  • BRAT1 tightly interacts with INTS9/INTS11 subunits of the Integrator complex that processes 3' ends of various noncoding RNAs and pre-mRNAs
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS