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FLASH GENE
Symbol SKOR1 contributors: mct - updated : 19-03-2009
HGNC name SKI family transcriptional corepressor 1
HGNC id 21326
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainhindbraincerebellum   Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral   
cells
SystemCellPubmedSpeciesStageRna symbol
NervousPurkinje cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text postmitotic neurons generated posterior to the midbrain-hindbrain border, in the developing spinal cord, selectively expressed in the dorsal horn interneurons
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies homolog to SKI oncoprotein
Homologene
FAMILY
  • Ski/Sno proto-oncoproteins family
  • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text in a nuclear dot-like structure
    basic FUNCTION
  • acting as a transcriptional corepressor for LBX1 in regulating cell fate determination in the dorsal spinal cord
  • neuronal lineage-specific transcriptional corepressor for the homeodomain transcription factor LBX1
  • molecular regulator of BMP signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • LBX1
  • interacts with SMAD1, SMAD2 and SMAD3 molecules and suppresses mainly BMP signaling pathway but has only minor effects on TGF-beta signaling
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS