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FLASH GENE
Symbol NSUN4 contributors: mct - updated : 06-10-2014
HGNC name NOP2/Sun domain family, member 4
HGNC id 31802
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel   highly
Digestiveintestinesmall intestine  moderately
Reproductivefemale systembreastmammary gland moderately
 female systemplacenta  moderately
 male systemtestis  moderately
Respiratoryrespiratory tractlarynx  predominantly
Visualeye   moderately
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • methyltransferase superfamily
  • RsmB/NOP family
  • NOL1/NOP2/Sun domain family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • with the NSUN4-CRISP2 complex play a role in the attainment of sperm functional competence
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • NSUN4/MTERF4 complex is required to assemble the small (SSU) and large subunit (LSU) of ribosome to form a monosome
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CRISP2-binding partner (CAP (CRISP/antigen 5/pathogenesis related-1) and CRISP domains of CRISP2 were required for maximal binding to NSUN4)
  • NSUN4 binds to the C-terminus of MTERF4
  • is thus a dual function protein, which on the one hand is needed for 12S rRNA methylation and, on the other hand interacts with MTERF4 to facilitate monosome assembly
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS