protein
| direct and specific interaction between the TRAF domain of TRAF3 and the TIM of MAVS is required for optimal MAVS-mediated antiviral responses |
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PSMA7 is a negative regulator of the MAVS-mediated innate immunity that probably serves to attenuate the establishment of an antiviral state during viral infection |
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binds DAP3 and induces anoikis by caspase activation |
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PCBP2 is a negative regulator in MAVS-mediated signaling |
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PCBP2 interaction with MAVS led to proteasomal degradation of MAVS (is recruited the HECT domain-containing E3 ligase ITCH to polyubiquitinate and degrade MAVS |
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related ubiquitin ligase TRAF5 is a downstream target of MAVS that mediates both IRF3 and NF-kappaB activation |
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RNF5 interacted with MAVS at mitochondria in a viral infection-dependent manner |
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TOMM70A is a mitochondrial import receptor, to interact with MAVS upon RNA virus infection |
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is required for B cell expression of TLR7 |
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ANKRD17 interacts with DDX58, IFIH1, and MAVS and upregulates RLR-mediated immune signaling |
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TSPAN6 functions as a negative regulator of the DDX58 pathway by interacting with MAVS in a ubiquitination-dependent manner |
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MAVS binds to VDAC1 and induces apoptosis by CASP3 activation, which is independent of its role in innate immunity |
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interacts with DDX58 and MAVS |
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interaction between the helicase DHX33 and MAVS (interaction between DHX33 and MAVS is mediated by the HELICc region of DHX33 and the C-terminal domain of MAVS) |
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MAVS facilitates the recruitment of NLRP3 to the mitochondria and may enhance its oligomerization and activation by bringing it in close proximity to mitochondrial reactive oxygen species |
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TRIM14 interacts with MAVS |
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DHX15 physically interacted with MAVS and mediated the MAVS-dependent activation of the NFKB1 and MAPK pathways |
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MARCH5 modulates MAVS-mediated antiviral signalling, preventing excessive immune reactions. |
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TAX1BP1 functions as an adaptor molecule for ITCH to target MAVS during RNA virus infection and thus restrict virus-induced apoptosis |
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TRIM31, an E3 ubiquitin ligase of the TRIM family of proteins, is a regulator of MAVS aggregation, and TRIM31 promotes aggregation and activation of the signaling adaptor MAVS through Lys63-linked polyubiquitination |
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RIPK3 interacts with MAVS to regulate type I IFN-mediated immunity to Influenza A virus infection |
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ZYX serves as a scaffold for the interactions between DHX58 and MAVS |
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HERPUD1 is a modulator of the ER stress response which is dependent on the participation of MAVS |
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through interacting with TBK1, HERPUD1 amplifies the MAVS signaling and facilitates the phosphorylation and nuclear translocation of IRF3 and NFKB1 to enhance the expression of IFNs, which leads to a broad inhibition of the replication of RNA viruses |
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BST2 is a negative regulator of DHX58-mediated type I IFN signaling by targeting MAVS |
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HAUS8 augments the Rig& |
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8209;like receptor (RLRs)& |
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8209;MAVS& |
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8209;dependent antiviral signaling pathway by targeting the MAVS complex |
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MAVS is a physiological substrate of SIRT5, and desuccinylation of MAVS by SIRT5 is critical for the modulation of MAVS activation in antiviral kinase cascade |
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SRP54 interacted with both DDX58 and IFIH1 and impaired their association with MAVS |
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