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FLASH GENE
Symbol SOSTDC1 contributors: mct/npt/pgu - updated : 09-09-2013
HGNC name sclerostin domain containing 1
HGNC id 21748
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
 vessel   moderately
Digestivestomach   highly
Urinarykidneytubuleconvoluted tubuledistal tubulehighly
 kidneynephronrenal capsuleglomerulushighly
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cells
SystemCellPubmedSpeciesStageRna symbol
Urinaryepithelial cell
Urinarypodocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a CTCK (C-terminal cystine knot-like) domain
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to rattus Usag1
    ortholog to murine Sostdc1
    intraspecies paralog to SOST
    Homologene
    FAMILY
  • sclerostin family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
    text secreted
    basic FUNCTION
  • may be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction
  • enhancing Wnt signaling
  • inhibiting TGF-beta signaling
  • directly antagonizing activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner, in the developing and adult kidney
  • negatively regulates the renoprotective action of BMP7
  • with MEOX2, may have a role in the progression of Wilms tumorigenesis
  • modulate Wnt signaling and also inhibit BMP signals, and modulation of Wnt signaling activity is brought about by an interaction with the Wnt co-receptor LRP6, whereas BMP inhibition is by binding to BMP ligands
  • having multiple functions at the molecular level, suggesting a possible role in balancing Wnt and BMP signals
  • plays crucial roles in tooth morphogenesis
  • uncovers the role of dental mesenchyme in limiting tooth induction
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    enhancing Wnt signaling ; inhibiting TGF-beta signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BMP2
  • BMP4
  • BMP6
  • BMP7
  • BMP antagonist
  • binds LRP6 through one of three loops formed by the cystine knot
  • HR repressed the expression of Wnt inhibitors, including SOSTDC1, DKKL1, SFRP1, and SFRP2
  • interplay between LRP4 and SOSTDC1 in inhibiting Wnt/CTNNB1 signaling, providing an insight into how modulation of Wnt/CTNNB1 signaling controls cellular processes important for skin placode formation
  • SOST and its paralog SOSTDC1 coordinate digit number in a GLI3-dependent manner
  • VDR-mediated control of DKKL1, SOSTDC1, and HR gene expression in keratinocytes
  • cell & other
  • binds to neighboring cells and/or the extracellular matrix
  • REGULATION
    induced by by IHH is independent of GLI1
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral somatic mutation      
    in Wilms tumor
    tumoral     --low  
    in renal clear cell carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerurinary 
    suppressing proliferation of renal carcinoma cells, restoration of SOSTDC1 signaling may represent a novel target in treatment of renal clear cell carcinoma
    ANIMAL & CELL MODELS
  • Wise-null mice phenocopied a subset of the Lrp4 mammary defects and Wise overexpression reduced the number of mammary precursor cells