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FLASH GENE
Symbol SLC25A37 contributors: mct/npt - updated : 21-03-2019
HGNC name solute carrier family 25, member 37
HGNC id 29786
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Lymphoid/Immunelymph node    
 spleen    
Nervousbrainforebraincerebral cortex highly
Olfactory (smell)olfactory bulb   highly
Reproductivefemale systemovary  highly
Respiratorylung    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmature hematopoietic
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text hematopoietic tissues
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • interaction domain with ABCB10 localized to the N terminus between the first 26 to 50 AAs (Chen 2009)
  • three solcar repeats
  • HOMOLOGY
    intraspecies homolog to SLC25A8
    Homologene
    FAMILY
  • mitochondrial carrier family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    intracellular,nucleus
    basic FUNCTION
  • may act as a carrier, exerting its suppressor activity via modulation of solute concentrations in the mitochondrion (possibly of cations)
  • mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells,
  • thereby playing an essential role in heme biosynthesis
  • functions as the principal mitochondrial iron importer essential for haem biosynthesis in vertebrate erythroblasts (Shaw 2006)
  • essential for heme and Fe/S cluster synthesis in erythroblasts and is required for primitive and definitive erythropoiesis (Chen 2009)
  • functions as an essential iron importer for the synthesis of mitochondrial heme and iron–sulfur clusters in erythroblasts (Chen 2009)
  • in erythroid cells, ferrous iron is imported into the mitochondrion by SLC25A37
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • FECH forms an oligomeric complex with SLC25A37 and ABCB10 to synergistically integrate mitochondrial iron importation and use for heme biosynthesis
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • physically interacts with ABCB10 (enhance its protein stability and, as a consequence, increase iron import into the mitochondria) (Chen 2009)
  • SLC25A37 interacts with ABCB10 to enhance mitochondrial iron importation
  • is a mitochondrial transporter of Fe used for heme formation by FECH and for 2Fe2S cluster synthesis, which is critical to FECH activity/stability
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS