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FLASH GENE
Symbol ZNF521 contributors: mct - updated : 18-11-2009
HGNC name zinc finger protein 521
HGNC id 24605
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel     Homo sapiens
Endocrineneuroendocrinepituitary  highly Homo sapiens
Hearing/Equilibriumearinnercochlea highly Homo sapiens
Nervousbrainhindbraincerebellum highly Homo sapiens
Reproductivefemale systemplacenta    Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticprogenitor cell Homo sapiens
cell lineage CD34+ progenitor, high expression in the most immature cells of the haematopoietic system and declines with differentiation
cell lines
fluid/secretion
at STAGE
physiological period embryo, pregnancy
Text
  • placenta
  • expressed in embryonic stem
  • cells, osteoblasts, chondrocytes and in subsets
    of neurons
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal transcriptional repressor motif with 13-AA motif, that binds to components of the nuclear remodelling and histone deacetylation (NuRD) complex and is conserved in several trascriptional co-repressors
  • 30 zinc finger domains
  • HOMOLOGY
    interspecies ortholog to murine Zfp521
    homolog to murine Evi3
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • inhibiting the transcriptional activity of early B-cell factor (EBF1), and regulating EBF1 activity in B-cell leukemia
  • playing a relevant role in the control of hematopoiesis and might be implicated in the development of hematopoietic malignancies
  • inhibitor of the transcription factor EBF1, implicated in the differentiation of neural progenitors and in the specification of the B-cell lineage
  • having a a possible role in development, stem cell regulation and oncogenesis
  • relevant player in the regulation of the homeostasis of the hematopoietic stem/progenitor cell compartment
  • plays an important role in the control of B-cell development by inhibiting the activity of EBF1, a master factor in B-lineage specification)
  • can antagonize B-cell development and may potentially contribute to conserve the multipotency of primitive lympho-myeloid progenitors by preventing or delaying their EBF1-driven commitment toward the B-cell lineage
  • could modulate B-cell development by suppressing
  • EBF1 activity and its molecular mechanism of action
  • appears to function as a transcriptional coactivator
  • together with EP300, adding to the functional
    diversity of ZNF521
  • is the intrinsic repressor of ZNF423 and hence of adipocyte commitment during BMP-induced mesenchymal precursor differentiation
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    member of the BMP signaling pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • interacting with EBF1 (misexpression of ZNF521 initiating tumorigenesis by perturbing B-cell development via an interaction with EBF1)
  • direct interaction of EHZF with GATA1 was demonstrated(EHZF modulates erythroid cell differentiation through direct binding with GATA1)
  • interacting with RUNX2 (the balance and molecular interplay between ZNF521 and RUNX2 contribute to the control of osteoblast differentiation, skeletal development, and bone homeostasis)
  • suppresses EBF1 activity via its C-terminal
  • zinc fingers
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    acute myelogenous leukemia
    tumoral     --over  
    in CD34+ progenitors and hematopoietic malignancies
    tumoral     --over  
    in most acute myelogenous leukaemias and is particularly high in those with rearrangements of the MLL gene, where EHZF may contribute to the leukaemic phenotype
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • is a cooperative gene for TCF3-HLF to develop acute B-lineage leukemia
  • Marker
    Therapy target
    ANIMAL & CELL MODELS