basic FUNCTION
| unique cytoskeletal structure located in the principal piece of the sperm flagellum |
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testis proteins, FMR1NB, NXF2, MAGEA5, FSIP1, and STARD6, are required for accurate chromosome segregation in tumor cells |
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is a component of the microtubule- and dynein-rich fibrous sheath structure, which is essential for flagellum function and sperm movement |
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overexpression of NXF2, FSIP1, and STARD6, in the absence of paclitaxel, increased the generation of multinucleated cells, a hallmark of aberrant mitosis |
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role of FSIP1 as well as mechanisms underlying FSIP1 action in drug sensitivity in breast cancer |
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regulates autophagy in breast cancer |
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FSIP1 has a crucial role in hormone receptor (HR)-positive breast cancer |