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FLASH GENE

Symbol

B4GALNT3

contributors: SGE - updated : 27-07-2010

HGNC name	beta-1,4-N-acetyl-galactosaminyl transferase 3
HGNC id	24137

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   highly   stomach       highly Reproductive male system testis     highly

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text

kidney

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an N-terminal transmembrane domain
	four potential N-glycosylation sites
	a DXH sequence thought to participate in divalent cation binding
	a C-terminal WGGED motif (Sato 2003)

HOMOLOGY

interspecies	homolog to murine B4galnt3 (84.7pc)
	homolog to rattus B4galnt3 (83.5pc)

Homologene

FAMILY

chondroitin N- acetylgalactosaminyltransferase family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi

basic FUNCTION	could transfer GalNAc residues, producing N, N'-diacetylgalactosediamine structures at least in N-glycans and probably in both N- and O-glycans
	up-regulation of B4GALNT3 may contribute to the malignant behavior of colon cancer cells (Huang 2007)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   overexpressed in colon cancer cell line, enhancing cell-extracellular matrix adhesion, migration, anchorage-independent growth and invasion (Huang 2007)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS