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FLASH GENE
Symbol QTRT1 contributors: - updated : 30-08-2005
HGNC name queuine tRNA-ribosyltransferase 1 (tRNA-guanine transglycosylase)
HGNC id 23797
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  moderately
 pancreas exocrine   highly
Nervousbrain   moderately
Reproductivefemale systemuteruscervix moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , dimer
HOMOLOGY
interspecies ortholog to murine Qtrt1
ortholog to rattus qtrt1 (84 pc)
Homologene
FAMILY queuine tRNA-ribosyltransferase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic,ribosome
basic FUNCTION
  • exchanging the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr)
  • involved in tRNA processing
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism nucleic
    signaling
    tRNA processing
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+ (1 zinc ion per subunit)
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS