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FLASH GENE
Symbol ARHGEF26 contributors: mct - updated : 15/11/2008
HGNC name Rho guanine nucleotide exchange factor (GEF) 26
HGNC id 24490
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Nervousbrain   moderately
Reproductivemale systemprostate  highly
 male systemtestis  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Digestivehepatocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • proline-rich N-terminus required to generate dorsal, but not lateral, membrane ruffles
  • a functional SH3 domain required to colocalize with filamentous actin at sites of membrane protrusion
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • involved in regulation of Rho guanosine triphosphatases
  • stimulated the formation of large interconnected membrane ruffles across dorsal surfaces when expressed in fibroblasts
  • a RhoG exchange factor that regulate membrane dynamics in promotion of macropinocytosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    new signaling pathway involving RHOG and its exchange factor SGEF downstream from ICAM1 that is critical for leukocyte trans-endothelial migration
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with RHOG (both SGEF and RhoG regulate membrane dynamics in promotion of macropinocytosis)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS