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FLASH GENE
Symbol BDH1 contributors: - updated : 27-02-2006
HGNC name 3-hydroxybutyrate dehydrogenase, type 1
HGNC id 1027
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly
 mouthtongue  highly
Lymphoid/Immunelymph node    
 thymus    
Nervousbrain   moderately
Reproductivefemale systemovary   
Respiratorylung   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Connectivebone   
Nervousperipherous   
cell lineage
cell lines
fluid/secretion blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 46-residue leader peptide cleaved to produce the mature form
  • secondary structure
  • predicted secondary structure motif of alternating alpha-helices and beta-sheets
  • mono polymer homomer , tetramer
    isoforms Precursor
    HOMOLOGY
    interspecies ortholog to rattus Bdh
    ortholog to murine Bdh
    intraspecies homolog to short-chain alcohol dehydrogenases (SCADHs), in the first two-thirds of the BDH protein
    Homologene
    FAMILY short-chain dehydrogenases/reductases (SDR) family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    basic FUNCTION
  • being a lipid-requiring mitochondrial enzyme with a specific requirement of phosphatidylcholine (PC)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism alcohol
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • NAD/NADH
  • protein
    cell & other
    REGULATION
    activated by phosphatidylcholine, in an allosteric action
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS