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FLASH GENE
Symbol ERLIN1 contributors: mct - updated : 30-12-2015
HGNC name ER lipid raft associated 1
HGNC id 16947
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveintestinelarge intestinecolon moderately
 intestinesmall intestine  moderately
Reproductivefemale systemuteruscervix moderately
 female systemplacenta  moderately
 male systemtestis  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
Connectivebone   
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • extreme N-terminus of ERLIN1 were found to be sufficient for heterologous targeting of GFP to the ER in the absence of classical ER retrieval motifs
  • HOMOLOGY
    interspecies ortholog to murine Spfh1
    Homologene
    FAMILY
  • band 7/mec-2 family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text membrane-associated
    basic FUNCTION
  • potential involvement in dendritic cells activation
  • ERLIN1/ERLIN2 complex is a factor that selectively mediates the ERAD of activated IP(3) receptors
  • ERLIN1, ERLIN2 promote stability of the SREBF-SCAP-INSIG complex and may contribute to the highly cooperative control of this system
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • ERLIN1/2 complex is composed of an assemblage of lower-order hetero-oligomers, probably heterotrimers, linked together by assembly domain hydrophobic AAs
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • multimeric ER proteins ERLIN1 and ERLIN2 are additional SREBF1, SREBF2 regulators
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPG62
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS