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FLASH GENE
Symbol JDP2 contributors: mct/npt/pgu - updated : 28-09-2016
HGNC name jun dimerization protein 2
HGNC id 17546
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systembreastmammary gland moderately
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal domain
  • a central basic region-leucine zipper domain
  • a putative consensus JNK docking-site
  • a corresponding phosphoacceptor site
  • a short non-conserved 40–50-AAs segment between the DNA binding domain and the ligand binding domain (LBD), termed the C-terminal extension (CTE), playing a role as a binding site for co-activator proteins
  • mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies ortholog to rattus Jundp2
    ortholog to murine Jundm2
    Homologene
    FAMILY
  • bZIP family
  • member of the AP-1 (activating protein-1) family of the basic leucine zipper transcription factors
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in the regulation of transcription, DNA-dependent
  • inhibitory subunit of the differentiation regulatory factor (DRF) complex
  • may play an important role in the RANK-mediated signal transduction system, especially in osteoclast differentiation
  • acting as a repressor functionally associated with HDAC3 to inhibit DDIT3 transcription
  • cooperates with various proteins to mediate regulatory activity
  • inhibitor of acetylation of histones and contributes to the maintenance of chromatin structure
  • plays a key role as a repressor of adipocyte differentiation by regulating the expression of the gene for C/EBPdelta via inhibition of histone acetylation
  • progesterone receptor-interacting protein enhancing the transcriptional activity of the N-terminal domain and can act in a manner independent of the ligand binding domain AF2
  • role as a regulator of the progression of normal cells through the cell cycle
  • AP1 family transcription factor that regulates the epigenetic status of histones
  • controls bone homeostasis and antibacterial immunity by regulating osteoclast and neutrophil differentiation
  • JDP2 plays a critical role as a cofactor NFE2L2 and MAFK in the regulation of the antioxidants and production of reactive oxygen species (ROS)
  • typically suppresses gene transcription through multiple mechanisms and plays a dual role in multiple cellular processes, including cell differentiation and proliferation which is dependent on AP1 function
  • plays a role as a histone chaperone and participates in diverse processes, such as cell-cycle arrest, cell differentiation, apoptosis, senescence, and metastatic spread, and functions as an oncogene and anti-oncogene, and as a cellular reprogramming factor
  • specific role of JDP2 in cellular-stress regulation and prevention
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • dimerizes with other AP-1 proteins such as activating transcription factor-2 (ATF2)
  • JDP2 is an integral component of the NFE2L2-MAFK complex and it modulates antioxidant and detoxification programs by acting via the antioxidant-responsive element (ARE)
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • recruited to the promoter of the gene for cyclin-A2 (CCNA2) at the AP-1 site (transcription of the gene for CCNA2 appears to be a direct target of JDP2 in the suppression of cell proliferation)
  • association of HDAC3 and HDAC6 with JDP2 and ATF3 occurs via direct protein-protein interactions
  • ATF3 was an inhibitor of neutrophil differentiation and JDP2 directly suppresses its expression via inhibition of histone acetylation
  • JDP2 associates with NFE2L2 and MAFK (NFE2L2-MAFK) to increase the transcription of antioxidant response element-dependent genes
  • JDP2 bound directly to the ARE core sequence, associated with NFE2L2 and MAFK (NFE2L2-MAFK) via basic leucine zipper domains, and increased DNA-binding activity of the NFE2L2-MAFK complex to the ARE and the transcription of ARE-dependent genes
  • TBX3 plays an important role in osteoclastogenesis at least in part by regulating CSF1-dependent expression of JDP2
  • DCLK1 efficiently phosphorylates JDP2, a possible target in the nucleus, with the aid of histones
  • cell & other
    REGULATION
    repressed by TP53 that significantly repressed the transcriptional activity of the JDP2 promoter
    Phosphorylated by on Thr148 by JNK (c-Jun N-terminal kinase) and MAPK14, although the functional role of its phosphorylation is targeting it for proteosomal degradation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • mice lacking Jdp2 (Jdp2-/-) display a reduced rate of metastasis in Lewis lung carcinoma (LLC) and polyoma middle T-antigen (PyMT) breast carcinoma mouse models
  • Jdp2(-/-) mice exhibited osteopetrosis resulting from impaired osteoclastogenesis