basic FUNCTION
| involved in the regulation of transcription, DNA-dependent |
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inhibitory subunit of the differentiation regulatory factor (DRF) complex |
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may play an important role in the RANK-mediated signal transduction system, especially in osteoclast differentiation |
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acting as a repressor functionally associated with HDAC3 to inhibit DDIT3 transcription |
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cooperates with various proteins to mediate regulatory activity |
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inhibitor of acetylation of histones and contributes to the maintenance of chromatin structure |
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plays a key role as a repressor of adipocyte differentiation by regulating the expression of the gene for C/EBPdelta via inhibition of histone acetylation |
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progesterone receptor-interacting protein enhancing the transcriptional activity of the N-terminal domain and can act in a manner independent of the ligand binding domain AF2 |
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role as a regulator of the progression of normal cells through the cell cycle |
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AP1 family transcription factor that regulates the epigenetic status of histones |
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controls bone homeostasis and antibacterial immunity by regulating osteoclast and neutrophil differentiation |
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JDP2 plays a critical role as a cofactor NFE2L2 and MAFK in the regulation of the antioxidants and production of reactive oxygen species (ROS) |
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typically suppresses gene transcription through multiple mechanisms and plays a dual role in multiple cellular processes, including cell differentiation and proliferation which is dependent on AP1 function |
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plays a role as a histone chaperone and participates in diverse processes, such as cell-cycle arrest, cell differentiation, apoptosis, senescence, and metastatic spread, and functions as an oncogene and anti-oncogene, and as a cellular reprogramming factor |
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specific role of JDP2 in cellular-stress regulation and prevention |