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FLASH GENE
Symbol ZNF346 contributors: mct - updated : 30-06-2012
HGNC name zinc finger protein 346
HGNC id 16403
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel   moderately
Digestivemouthtongue  moderately
Lymphoid/Immunethymus   predominantly
Nervousbrain   moderately
Reproductivefemale systembreastmammary gland moderately
 female systemuterus  moderately
 male systemprostate  moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four homologous C2H2-type zinc finger domains
  • unusually long helix-loop linker sequences beginning with basic residues
  • HOMOLOGY
    interspecies ortholog to murine Zfp346
    Homologene
    FAMILY
    CATEGORY regulatory , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • involved in cell growth and survival
  • functions to mediate G1 cell-cycle arrest followed by apoptosis in a TP53-dependent mechanism that is associated with up-regulation of CDKN1A and BAX, and dephosphorylation of RB
  • novel negative regulator of cell growth by positively regulating TP53
  • unique dsRNA binding zinc finger protein that functions as a direct, positive regulator of TP53 transcriptional activity to mediate G1 cell cycle arrest
  • plays a dual role in cell cycle regulation by both repressing E2F1 transcriptional activity and activating p53 to facilitate efficient growth arrest in response to cellular stress
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism nucleic
    signaling
  • RNA processing
  • a component
    INTERACTION
    DNA
  • RNA/DNA hybrids
  • RNA
  • double-stranded RNA
  • RNA/DNA hybrids
  • small molecule metal binding,
  • Zn2+
  • protein
  • associates with TP53 to stimulate its transcriptional activity in TP53-expressing cells
  • can also negatively regulate the cell cycle in a novel, TP53-independent mechanism resulting from the direct interaction with E2F1, a key intermediate in regulating cell proliferation and tumor suppression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS