basic FUNCTION
| involved in cell growth and survival |
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functions to mediate G1 cell-cycle arrest followed by apoptosis in a TP53-dependent mechanism that is associated with up-regulation of CDKN1A and BAX, and dephosphorylation of RB |
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novel negative regulator of cell growth by positively regulating TP53 |
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unique dsRNA binding zinc finger protein that functions as a direct, positive regulator of TP53 transcriptional activity to mediate G1 cell cycle arrest |
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plays a dual role in cell cycle regulation by both repressing E2F1 transcriptional activity and activating p53 to facilitate efficient growth arrest in response to cellular stress |