Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol IPMK contributors: mct - updated : 28-06-2013
HGNC name inositol polyphosphate multikinase
HGNC id 20739
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   moderately
 stomach   highly
Reproductivefemale systemuterus  moderately
 male systemtestis  moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to rattus Ipmk
ortholog to murine Ipmk
Homologene
FAMILY
  • inositol phosphokinase (IPK) family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    text
  • nucleocytoplasmic shuttling protein, whose nuclear export is mediated by classical nuclear export receptor XPO1
  • basic FUNCTION
  • inositol phosphate kinase with a broad substrate specificity
  • having a preference for inositol-1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,6-tetrakisphosphate
  • may regulate the level of Ins(1,4,5,6)P4 and have an effect on chloride channel regulation
  • the most catalytically diverse member of this family with critical roles in nuclear functions including mRNA export, transcriptional regulation, and chromatin remodeling
  • regulates glucose signaling to AMPK in a pathway whereby glucose activates phosphorylation of IPMK at tyrosine 174 enabling the enzyme to bind to AMPK and regulate its activation
  • role for the hypothalamic IPMK signaling in the control of AMPK and central energy homeostasis
  • multifunctional protein in cellular signal transduction, namely, a multispecific inositol phosphate kinase, phosphatidylinositol 3-kinase, and a scaffold within the MTOR-raptor complex
  • is a versatile player in insulin-, nutrient-, and energy-mediated metabolism signaling networks
  • acts potentially as a transcriptional coactivator for TP53 and it is an integral part of the TP53 transcriptional complex facilitating cell death
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • possesses both inositol phosphate kinase and lipid kinase activities, regulates amino acid signaling to MTOR
  • physiologically binds AMPK, with binding enhanced by glucose treatment
  • DVL3 translocates IPMK to the cell membrane in response to Wnt
  • stimulated TP53-mediated transcription by binding to TP53 and enhancing its acetylation by the acetyltransferase EP300 independently of its inositol phosphate and lipid kinase activities
  • cell & other
    REGULATION
    repressed by CSNK2A1 (CSNK2A1 binds endogenous IPMK and phosphorylates it at serine 284)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabetemetabolic syndrom 
    Agents that control IPMK functions may provide novel therapeutics in metabolic syndromes such as obesity and diabetes
    diabetetype 2 
    Substances that block IPMK-mTORC1 binding may afford therapeutic benefit in nutrient amino acid-regulated conditions such as obesity
    obesity  
    Substances that block IPMK-mTORC1 binding may afford therapeutic benefit in nutrient amino acid-regulated conditions such as diabetes
    ANIMAL & CELL MODELS