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FLASH GENE
Symbol IL27RA contributors: mct/pgu - updated : 04-12-2009
HGNC name interleukin 27 receptor, alpha
HGNC id 17290
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  predominantly
 stomach   highly
Lymphoid/Immunelymph node   highly
 spleen   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow    Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
Blood/Hematopoieticprogenitor cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three fibronectin type-III domains
  • a box 1 motif, required for JAK interaction and/or activation
  • a WSXWS motif, necessary for proper protein folding and thereby efficient intracellular transport and cell- surface receptor binding
  • seven potential N-glycosylation sites in its extracellular domain
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Il27ra
    Homologene
    FAMILY
  • type I cytokine receptor family
  • type 2 subfamily
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I membrane protein
    basic FUNCTION
  • acting as a receptor for IL27
  • required IL6ST/gp130 to mediate signal transduction in response to IL27 (through STAT3 and STAT1)
  • involved in the regulation of Th1-type immune responses
  • also appearing to be involved in innate defense mechanisms
  • can trigger signaling in T cells, B cells, and myeloid cells
  • possesses hematopoietic cell-transforming properties, can enhance activation of JAK2 and may be involved in myeloproliferative disorders
  • both CNTFR and IL27RA may be involved in MTRNR2L1 binding to cells
  • highly expressed in epithelial tumor cells where it inhibits tumor growth by enhancing natural killer cytolytic activity
  • soluble IL27RA may play important immunoregulatory functions under normal and pathological conditions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • complexing with IL6ST and CNTFR to form the IL27 receptor
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • a soluble isoform also interacts with IL6ST and CNTFR and forms an alternative functional humanin (anti-Alzheimer's disease rescue factor) receptor
  • MTRNR2L1 inhibits neuronal cell death and dysfunction by binding to a novel IL6-receptor-related receptor(s) on the cell surface involving CNTFR, IL27RA, and IL6ST
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS