basic FUNCTION
| acting as a receptor for IL27 |
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required IL6ST/gp130 to mediate signal transduction in response to IL27 (through STAT3 and STAT1) |
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involved in the regulation of Th1-type immune responses |
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also appearing to be involved in innate defense mechanisms |
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can trigger signaling in T cells, B cells, and myeloid cells |
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possesses hematopoietic cell-transforming properties, can enhance activation of JAK2 and may be involved in myeloproliferative disorders |
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both CNTFR and IL27RA may be involved in MTRNR2L1 binding to cells |
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highly expressed in epithelial tumor cells where it inhibits tumor growth by enhancing natural killer cytolytic activity |
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soluble IL27RA may play important immunoregulatory functions under normal and pathological conditions |