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FLASH GENE
Symbol FGD6 contributors: - updated : 07-06-2005
HGNC name FYVE, RhoGEF and PH domain containing 6
HGNC id 21740
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel   highly
Digestivemouthtongue  highly
Lymphoid/Immunelymph node   predominantly
Reproductivefemale systemuteruscervix highly
 female systembreastmammary gland moderately
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Fgd6
Homologene
FAMILY
CATEGORY regulatory , structural protein
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,Golgi
intracellular,cytoplasm,cytoskeleton
text lamellipodium and ruffle
basic FUNCTION
  • acting as a guanyl-nucleotide exchange factor
  • involved in actin cytoskeleton organization and biogenesis
  • playing a role filopodium formation
  • involved in regulation of cell shape
  • CELLULAR PROCESS cell life, proliferation/growth
    cell organization/biogenesis
    cell migration & motility
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS