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FLASH GENE
Symbol ASAP3 contributors: mct/pgu - updated : 23-02-2013
HGNC name ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
HGNC id 14987
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
Endocrineparathyroid   highly
Reproductivemale systemtestis  highly
Respiratoryrespiratory tractlarynx  predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an Arf GTPase-activating protein (ArfGAP) domain
  • two ankyrin repeats
  • one pleckstrin homology domain (PH) required for efficient catalytic activity of the protein
  • a BAR domain
  • a proline-rich
  • SH3 domains
  • HOMOLOGY
    interspecies ortholog to murine Ddefl1
    intraspecies homolog to DDEF/ASAP1
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text associated with focal adhesions and circular dorsal ruffles
    basic FUNCTION
  • promoting proliferation of cells
  • regulation of GTPase activity
  • Arf GTPase-activating protein implicated in the pathogenesis of hepatocellular carcinoma, and that may regulate cell migration associated with the invasion of normal tissue by cancer cells
  • having functions nonredundant with ASAP1 to control cell movement and may have a role in cancer cell invasion
  • present in cell structures required for cell migration and invasion, such as focal adhesions, invadopodias, and podosomes, and are involved in endocytosis and cytoskeletal remodeling 0)
  • involvement in carcinogenesis and metastasis highlights the importance of the presented structure in general and the Ca2+-binding pocket in particular as it may give clues for designing inhibitors for therapeutic applications
  • novel function for ASAP3 in the regulation of cell migration through controlling ITGB1 dynamics
  • important regulator in cancer cell migration/invasion and actin-based cytoskeletal remodeling
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    carboxylic acid metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with ARF6 (has a phosphatidylinositol 4,5-bisphosphate-dependent GAP activity specific for ARF6)
  • ARF6 GTPase-activating protein, essential for EGF-induced cell migration
  • regulates ITGB1 dynamics during EGF-stimulated cell migration by interaction with GRB2
  • ASAP3 linked with ACTG1 in the regulation of cytoskeletal maintenance and cell motility
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    up-regulated in hepatocellular carcinomas (HCCs)
    constitutional     --low  
    reduced actin stress fibers
    Susceptibility
    Variant & Polymorphism
    Candidate gene for new strategies for diagnosis and treatment of HCC
    Marker
    Therapy target
    ANIMAL & CELL MODELS