Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CCAR1 contributors: mct - updated : 26-12-2018
HGNC name cell division cycle and apoptosis regulator 1
HGNC id 24236
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestivemouthtongue   
Reproductivemale systemprostate   
Respiratoryrespiratory tractlarynx  highly
Urinarybladder    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nucleus,nucleoplasm
text
  • NEUROG3 and CCAR1 are co-localized in the nucleus
  • basic FUNCTION
  • key mediator of signaling by CD437 or adriamycin allows for delineation of pathways that, in turn, may prove beneficial for design and targeting of novel antitumor agents
  • apoptosis inducer, that regulates apoptosis signaling by diverse agents, including adriamycin and growth factors
  • promotes apoptosis by activating MAPK14 and caspase-9, and is involved in apoptosis signaling by epidermal growth factor receptor
  • regulates expression of key proliferation-inducing genes
  • also functions as a TP53 coactivator, suggesting a broader role in transcriptional regulation
  • function as a transcriptional coactivator for nuclear receptors, also interacts with beta-catenin and enhances the ability of beta-catenin to activate expression of transiently transfected reporter genes
  • perinuclear phospho-protein, regulating signaling by adriamycin, steroids, or growth factors (
  • important co-activator for estrogen-induced gene expression and estrogen-dependent growth of breast cancer cells
  • can serve as a co-activator for different classes of transcription factors to maintain the balance of proliferation, apoptosis, and differentiation
  • potential role in PTH signaling and bone anabolic action
  • positively regulates adipocyte differentiation through the glucocorticoid signaling pathway
  • CCAR2 and CCAR1 are largely disordered proteins that have evolved from one common ancestor
  • plays a dynamic role in regulation of cell growth and apoptosis by serving as a cofactor of steroid/thyroid nuclear receptors, CTNNB1, and TP53 in a variety of cell types including different cancer cells
  • CCAR1 contributes to carcinogenesis in gastric cancer and is required for the survival of gastric cancer cells
  • CCAR1 is a novel transcriptional cofactor for NR1I3
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • novel component of Wnt/beta-catenin signaling that plays an important role in transcriptional regulation by beta-catenin
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • 14-3-3 protein as well as causes reduced expression of cell cycle regulatory genes including c-Myc and cyclin B1
  • microtubule dependent association of AKAP9 and CCAR1 with RNA stress granules
  • binds with signal transducer TAZ and over-expression of TAZ inhibits apoptosis by CCAR1
  • transcriptional coactivator for nuclear receptors, also interacts with NEUROG3
  • NDN exerts its pro-survival activity by counteracting the action of the pro-apoptotic protein Cell Cycle Apoptosis Regulatory Protein (CCAR1/CARP1)
  • can act as an enhancer-dependent coactivator of NR1I3 1)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in hepatocellular carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may serve as a diagnostic marker in gastric cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    may represent a novel target for therapeutic intervention in cancers involving aberrantly activated Wnt/beta-catenin signaling
    cancer  
    SRSF5-CCAR1 axis may be valuable targets for cancer therapeutics
    cancerdigestivestomach
    potential therapeutic target in gastric cancer
    ANIMAL & CELL MODELS