basic FUNCTION
| key mediator of signaling by CD437 or adriamycin allows for delineation of pathways that, in turn, may prove beneficial for design and targeting of novel antitumor agents |
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apoptosis inducer, that regulates apoptosis signaling by diverse agents, including adriamycin and growth factors |
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promotes apoptosis by activating MAPK14 and caspase-9, and is involved in apoptosis signaling by epidermal growth factor receptor |
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regulates expression of key proliferation-inducing genes |
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also functions as a TP53 coactivator, suggesting a broader role in transcriptional regulation |
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function as a transcriptional coactivator for nuclear receptors, also interacts with beta-catenin and enhances the ability of beta-catenin to activate expression of transiently transfected reporter genes |
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perinuclear phospho-protein, regulating signaling by adriamycin, steroids, or growth factors ( |
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important co-activator for estrogen-induced gene expression and estrogen-dependent growth of breast cancer cells |
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can serve as a co-activator for different classes of transcription factors to maintain the balance of proliferation, apoptosis, and differentiation |
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potential role in PTH signaling and bone anabolic action |
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positively regulates adipocyte differentiation through the glucocorticoid signaling pathway |
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CCAR2 and CCAR1 are largely disordered proteins that have evolved from one common ancestor |
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plays a dynamic role in regulation of cell growth and apoptosis by serving as a cofactor of steroid/thyroid nuclear receptors, CTNNB1, and TP53 in a variety of cell types including different cancer cells |
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CCAR1 contributes to carcinogenesis in gastric cancer and is required for the survival of gastric cancer cells |
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CCAR1 is a novel transcriptional cofactor for NR1I3 |
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