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FLASH GENE
Symbol SPSB1 contributors: mct - updated : 08-12-2020
HGNC name splA/ryanodine receptor domain and SOCS box containing 1
HGNC id 30628
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue  highly
 pancreas exocrine   highly
Endocrinethyroid   highly
Reproductivefemale systemovary  highly
 female systemplacenta  highly
Respiratorylung   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a central SPRY domain
  • a C-terminal SOCS box
  • conjugated PhosphoP
    HOMOLOGY
    intraspecies paralog to SPSB4
    Homologene
    FAMILY
  • suppressor of cytokine signaling (SOCS) protein family
  • SPRY (repeats in splA and RyR) domain-containing SOCS box protein (SSB) subfamily
  • SOCS box family of E3 ubiquitin ligases
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • may play an important role in enhancing the HGF-induced Erk-Elk-1-SRE pathway
  • prominent role of SPSB1 in limiting NFKB1 activation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    intracellular signaling cascade
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with MET(bound to MET tyrosine kinase domain through its SPRY domain, in both the absence and the presence of HGF)
  • SPSB1 and SPSB4 bind strongly to both Par-4 and DDX4 peptides
  • SPSB1, SPSB2, SPSB4 can induce the subcellular redistribution of NOS2 from dense regions to diffused expression in a SOCS box-dependent manner
  • RAS enhances TGFB1 signaling by decreasing cellular protein levels of its type II receptor negative regulator SPSB1
  • SPSB1 and SPSB2 are key physiological regulators of NOS2
  • SPSB1 enhances ovarian cancer cell survival by destabilizing CDKN1A
  • paralogs SPSB1 and SPSB4, but not SPSB2 and SPSB3, can interact with and facilitate NR1D1 ubiquitination and degradation and regulate circadian clock periodicity
  • cell & other
    REGULATION
    Other in response to HGF stimulation, became phosphorylated at tyrosine residue 31
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS