basic FUNCTION
| may have acetyltransferase activity and may be required for the establishment of sister chromatid cohesion during the S phase of mitosis |
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having a function in transcription repression through modulation of the chromatin structure |
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having transcriptional repression activity through its interacting proteins |
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required for proper sister chromatid cohesion (van der Lelij 2009) |
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having an S phase-specific role in the maintenance of genome stability (van der Lelij 2009) |
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acetyltransferase that is required for the establishment of sister chromatid cohesion |
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may play an important role in neurogenesis by attenuating Notch signaling to promote neuronal differentiation |
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ESCO2 functions non-redundantly with ESCO1 |
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is needed for cohesin acetylation in pericentric heterochromatin and this modification is required for the proper distribution of cohesin on mitotic chromosomes and for centromeric cohesion |
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is also required for double-strand break (DSB) repair, which is consistent with previous studies in RBS cells |
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may play a vital role in meiosis in both males and females |