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FLASH GENE
Symbol CCDC34 contributors: mct - updated : 30-11-2022
HGNC name coiled-coil domain containing 34
HGNC id 25079
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivestomach   moderately
Lymphoid/Immunethymus   highly
Reproductivefemale systemuteruscervix lowly
 male systemtestis  lowly
cell lineage
cell lines
fluid/secretion blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY protooncogene
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • potential oncogenic role for CCDC34 in bladder carcinoma pathogenesis
  • promotes cell proliferation and invasive properties in human cancer
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SPGF76
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    predicted the poor outcomes among hepatocellular carcinoma (HCC) patients
    tumoral     --over  
    in bladder cancer tissues and cell lines
    tumoral     --over  
    in pancreatic adenocarcinoma compared with normal pancreatic tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • will become a promising prognostic biomarker and therapeutic target against HCC
  • may serve as a biomarker for bladder cancer
  • increased CCDC34 expression was an independent predictor of poor patient prognosis in pancreatic adenocarcinoma
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    promising therapeutic target against HCC
    cancerurinary 
    therapeutic target for bladder cancer
    ANIMAL & CELL MODELS