protein
| interacting with MCM2, MCM3, MCM4, MCM5, MCM6, MCM7 (Numata 2010) |
|
RPA1-covered ssDNA not only supports recruitment and activation of ATR but also, through TIPIN and CLSPN, it plays an important role in the action of ATR on its critical downstream target CHEK1 |
|
RPA2 also interacts with TIPIN during the intra-S checkpoint |
|
TIMELESS protein associates with S phase replication checkpoint proteins CLSPN and TIPIN , and plays an important role in maintaining replication fork stability at physical barriers, like centromeres, telomeres and ribosomal DNA repeats, as well as at termination sites |
|
ARHGEF5-TIPIN complex might couple DNA unwinding and DNA synthesis by affecting the biochemical properties of these replisome proteins |
|
ARHGEF5 is responsible for the interaction between the ARHGEF5-TIPIN and Mcm complexes |
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MTA2, a subunit of the NuRD chromatin remodeler complex, is a novel TIPIN binding partner and mediator of its function |