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FLASH GENE

Symbol

CAB39

contributors: mct/npt/pgu - updated : 16-06-2021

HGNC name	calcium binding protein 39
HGNC id	20292

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth tongue         stomach       highly Endocrine parathyroid       highly Lymphoid/Immune lymph node       highly   thymus         Nervous brain         Urinary bladder           kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone       Muscular striatum skeletal

cell lineage
cell lines
fluid/secretion	blood

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

Mo25 family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,cytosolic,granule
	intracellular,nucleus

basic FUNCTION	with the LYK5 alpha pseudo kinase, forming a regulatory complex capable of stimulating the activity of STK11
	scaffold protein to which other regions of STRADA-STK11, cellular STK11 substrates or regulatory components could bind
	involved with SRADA in STK11 activity
	has roles beyond controlling STK11
	has evolved as a key regulator of a group of STE20 kinases and may represent an ancestral mechanism of regulating conformation of pseudokinases and activating catalytically competent protein kinases
	key regulator of a group of sterile 20 kinases
	played very important oncogenic roles in hepatocellular carcinoma (HCC) pathogenesis and progression by activating the ERK signaling pathway

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

core heterotrimeric STK11-STRADA-CAB39 complex, implicated in unusual allosteric mechanism of STK11 activation

INTERACTION

DNA

RNA

small molecule

protein	associated with LKB1-STRADalpha complex (STK11)
	interactions between STRADA and CAB39 involving the alphaC-helix of STRADA, reminiscent of the mechanism by which CDK2 interacts with cyclin A
	interaction with STRADA (activates the STK11 tumour suppressor by forming a heterotrimeric complex with STK111 and the scaffolding protein CAB39
	interaction between CAB39 and a serine/threonine kinase termed MST4
	CAB39 targets are STK39, regulators of ion homeostasis and blood pressure, and STK24/MST4, involved in controlling development and morphogenesis
	CAB39 is a binding partner and enhancer of STK39/OSR1 activity, facilitating kinase autoactivation and promoting phosphorylation of the cotransporters

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       gain of function in hepatocellular carcinoma (HCC),and significantly associated with tumor metastasis and poorer disease-free survival rate

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS