basic FUNCTION
| interacting with proteins involded in the network for human inherited ataxias and disorders of Purkinje cell degeneration |
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ELP4, ELP5, and ELP6--are required for histone acetyltransferase (HAT) activity, and Elongator binds to both naked and nucleosomal DNA |
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may be involved in p53-mediated gene transcription |
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plays an important role in RNA polymerase II-mediated transcriptional elongation and many other processes, including cytoskeleton organization, exocytosis, and tRNA modification 6) |
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ELP5 and ELP6 are key players for migration, invasion and tumorigenicity of melanoma cells, as integral subunits of Elongator |
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ELP1, ELP2, ELP3, ELP4, ELP5, ELP6 plays vital roles in gene regulation |