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FLASH GENE
Symbol ELP5 contributors: mct - updated : 27-02-2017
HGNC name elongator acetyltransferase complex subunit 5
HGNC id 30617
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart     Homo sapiens
Digestiveliver     Homo sapiens
Nervousbrainhindbraincerebellum  
Reproductivemale systemtestis    Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal   Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
NervousPurkinje cell
cell lineage
cell lines
fluid/secretion
at STAGE
cell cycle     cell cycle, S
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Rai12
ortholog to rattus derp6
Homologene
FAMILY
CATEGORY unknown/unspecified
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus
basic FUNCTION
  • interacting with proteins involded in the network for human inherited ataxias and disorders of Purkinje cell degeneration
  • ELP4, ELP5, and ELP6--are required for histone acetyltransferase (HAT) activity, and Elongator binds to both naked and nucleosomal DNA
  • may be involved in p53-mediated gene transcription
  • plays an important role in RNA polymerase II-mediated transcriptional elongation and many other processes, including cytoskeleton organization, exocytosis, and tRNA modification 6)
  • ELP5 and ELP6 are key players for migration, invasion and tumorigenicity of melanoma cells, as integral subunits of Elongator
  • ELP1, ELP2, ELP3, ELP4, ELP5, ELP6 plays vital roles in gene regulation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • core Elongator complex formed by IKBKAP, ELP2, and ELP3 was rather stable, whereas ELP4, ELP5, and ELP6 might loosely contact and work together with the core Elongator to regulate cell functions
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ELP6 acts as a bridge to assemble ELP4 and ELP5 6)
  • is required for the integrity of Elongator and directly connects ELP3 to ELP4
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS