basic FUNCTION
| represent regulators of cell death pathways (Zhou 2008) |
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play a role in apoptosis |
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is a regulator of intracellular Ca2+ fluxes and apoptosis |
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can oligomerize in a pH-regulated manner, and monomeric TMBIM4 is functional |
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increased cell adhesion, spreading, and migration in a manner that depended on its C-terminal domain |
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Golgi antiapoptotic proteins (GAAP) are highly conserved Golgi membrane proteins that inhibit apoptosis and promote Ca(2+) release from intracellular stores |
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is a novel regulator of focal adhesion dynamics, cell adhesion, and migration by controlling localized Ca(2+)-dependent activation of calpain |
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reduce the CaČ& |
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8314; content of the endoplasmic reticulum, and all but TMBIM5 also reduce the cytosolic resting CaČ& |
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8314; concentration |