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FLASH GENE
Symbol AMIGO2 contributors: - updated : 18-02-2006
HGNC name amphoterin induced gene 2
HGNC id 24073
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemovary   
 female systembreastmammary gland highly
Urinarybladder   highly
 kidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal sequence for secretion
  • a transmembrane domain
  • six leucine-rich repeats (LRRs) flanked by
  • cysteine-rich LRR NH2- and COOH-terminal domains
  • one immunoglobulin domain close to the transmembrane region
  • HOMOLOGY
    Homologene
    FAMILY AMIGO family
    CATEGORY adhesion , regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • promoting depolarization-dependent survival of the cerebellar granule neuron and inhibiting apoptosis
  • playing a potential etiologic role in gastric adenocarcinoma
  • CELLULAR PROCESS cell life, antiapoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastric adenocarcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS