| Ars2 nuclear localization is ablated in ARS2-null embryos, which in turn die around the time of implantation, ARS2-null blastocysts contained a significantly greater number of apoptotic cells than wild-type or heterozygous blastocysts | |
Deletion of Ars2 is developmentally lethal, and deletion in adult mice led to bone marrow failure whereas parenchymal organs composed of nonproliferating cells were unaffected |
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selective knockdown of Ars2 in cells expressing glial fibrillary acidic protein within the adult subventricular zone depletes the number of neural stem cells and their neurogenic capacity |