Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol HINFP contributors: mct/npt - updated : 08-06-2022
HGNC name histone H4 transcription factor
HGNC id 17850
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
 liver   highly
Lymphoid/Immunespleen   highly
Nervousbrain   highly
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven zinc finger domains similar to the C2H2 zinc finger motif
  • a stretch of negatively charged amino acids
  • specific conserved region (PSCR) located within the C-terminus that is present in HINFP homologues of all metazoan species, required for activation of histone H4 gene transcription and contributing to DNA binding of HINFP (Medina 2008)
  • HOMOLOGY
    Homologene
    FAMILY
  • zinc finger transcription factor family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • playing a role in DNA methylation and transcription repression
  • HiNFP-dependent stabilization of NPAT may reinforce signaling through the cyclin E/CDK2/NPAT pathway and contribute to coordinate control of histone gene expression (Medina 2006)
  • unique cell cycle regulatory member of the zinc finger transcription factor family (Medina 2008)
  • in addition to histone genes, also regulates expression of nonhistone targets that influence competency for cell cycle progression (Medina 2007)
  • bifunctional transcriptional regulator that can activate or repress cell cycle controlled genes depending on the cellular context (Mitra 2007)
  • final and essential link in the CCNE1/CDK2/NPAT/HINFP pathway that is required for cell cycle-dependent activation of histone H4 genes at the G1/S phase transition (Xie 2009)
  • regulator of histone H4 gene expression in all proliferating cell types and is essential for embryonic survival beyond the blastocyst stage (Xie 2009)
  • acting as a unique and irreplaceable transcription factor that functions as part of a CDK2 responsive gene regulatory mechanism that controls progression beyond the G1/S phase transition (Xie 2009)
  • mediates cell cycle control of histone H4 gene expression to support the packaging of newly replicated DNA as chromatin
  • simultaneous loss of both HINFP and the TP53 checkpoint is detrimental to normal cell growth and may predispose to cellular transformation
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with methyl-CpG-binding protein-2 (MBD2)
  • with its cofactor p220(NPAT) are principal factors regulating histone gene expression at the G(1)-S phase cell cycle transition (Medina 2007)
  • HINFP is a co-activator in SREBF-mediated transactivation of PCSK9 gene expression
  • is essential for expression of histone H4 genes
  • transmission of maternal HINFP transcripts and zygotic activation of the HINFP gene together are necessary to control H4 gene expression in early pre-implantation embryos in order to support normal embryonic development
  • is a physiological regulator of Histone1-dependent silencing of most transposable elements, as well as many host genes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    associated with senescence in bladder cancer (BC) tissues and lower HINFP expression could predict an unfavorable outcome in BC patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS